Employing single-molecule optical and AFM imaging and force-spectroscopy procedures, we search for to unravel the mechanistic facets of the structure and dynamics of chromosomes. Our investigate passions contain:

Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transport of macromolecules

‘It had been merely a matter of buying up a ebook on cell biology and beginning to examine. I had originate from a earth of extremely-large vacuums, cryostats and quantum phenomena, and now I was Performing at area temperature with molecular biology kits.

Nanofabrication of electrodes with sub-5 nm spacing for transportation experiments on single molecules and metallic clusters

2010, developed a brand new way (‘wedging transfer’) to manipulate nanostructures; to start with report of DNA translocation by graphene nanopores; and recognized hybrid nanopores by directed insertion of α-hemolysin into sound-state nanopores

Our exploration ranges from your biophysics of DNA to synthetic cells and outside of. Remember to take a look underneath in the spectrum of our recent assignments.

‘In the beginning we checked out Organic methods by using a Actual physical see and acted on The idea with the tools we knew. It took a couple of years in advance of we started Operating far more on the massive Organic issues. I then started to simply call it nanobiology, a time period that did not exist at the time.

Flow-driven rotary motors for example windmills and h2o wheels drive practical processes in human Culture. While samples of these types of rotary motors also function prominently in cell biology, their synthetic building with the nanoscale has remained complicated. Here we show circulation-driven rotary movement of the self-arranged DNA nanostructure which is docked onto a nanopore in a skinny reliable-condition membrane. An elastic DNA bundle self-assembles into a chiral conformation on phoretic docking on to the sound-state nanopore, and subsequently shows a sustained unidirectional rotary movement of up to 20 rev s−one.

Imagine if, rather than employing conventional best-down silicon electronics, transistors can be constructed from the bottom up working with single natural molecules as being the switching features? This idea, which became The idea of currently’s field of molecular electronics, very first emerged from the nineteen seventies.

At the moment, we also realized that it should be possible to employ one semiconducting carbon nanotube to produce a transistor — and we set out to really make it. We stretched personal semiconducting nanotubes throughout metallic electrodes and utilised the underlying silicon substrate as being a gate electrode, creating The fundamental a few-terminal format of a subject-impact transistor (Fig.

Because 2000 he moved to solitary-molecule biophysics and nanobiology, with research from reports of DNA loop extrusion and supercoiling to DNA translocation through nanopores. Far more recently his analysis has centered on studying chromatin construction and mobile division with microbes on chip, whilst he https://www.ceesdekker.net is likewise attempting to eventually Establish synthetic cells from the bottom up.

Numerous new phenomena were being identified, and he and his investigate group recognized a leading placement During this discipline of investigate. Dekker and his analysis team discovered new physics of nanotubes and also explored the feasibility of molecular electronics. In 1998, they were being the initial to make a transistor according to an individual nanotube molecule.

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 Lastly, I will briefly sketch some of our Suggestions to explore the developing of artificial cells, precisely our first methods to establish artificial cell division.